Description

4-Methoxypicolinimidamide Hydrochloride is a high-purity chemical intermediate of significant importance in modern pharmaceutical research and development. This compound serves as a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex heterocyclic scaffolds. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of kinase inhibitors and other targeted small-molecule therapies. The material is supplied with a focus on batch-to-batch consistency and reliable purity to support rigorous R&D and scale-up processes.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of protein kinase inhibitors for oncology and inflammatory disease research.
• Chemical Biology Probe Development: Used to create tool compounds for studying specific enzyme functions and signaling pathways.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization.
• Active Pharmaceutical Ingredient (API) Synthesis: Incorporated into the final chemical structure of investigational new drugs.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic and medicinal chemistry.

Basic Information

Product Name	4-Methoxypicolinimidamide Hydrochloride
CAS No.	1179361-66-0
Molecular Formula	C7H10N3O•HCl
Molecular Weight	187.63 g/mol (Free base: 151.17 g/mol)
Synonyms	4-Methoxypyridine-2-carboximidamide hydrochloride; 2-Pyridinecarboximidamide, 4-methoxy-, hydrochloride; 4-Methoxy-2-pyridinecarboximidamide monohydrochloride; 4-Methoxypicolinamidine hydrochloride; Picolinimidamide, 4-methoxy-, hydrochloride; 4-Methoxy-2-carbamimidoylpyridine hydrochloride
EINECS	Contact for details

Quality Control

Our 4-Methoxypicolinimidamide Hydrochloride is manufactured under a quality management system and undergoes rigorous analytical testing to ensure it meets the stringent requirements for pharmaceutical R&D. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While not a compendial item, quality is assured against in-house specifications developed in alignment with ICH Q3A/B guidelines for impurities in new drug substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.