Description

5-Bromo-1-Methyl-3-(5-(4-Methylpiperazin-1-Yl)Pyridin-2-Ylamino)Pyridin-2(1H)-One CAS NO 1178884-45-1 is a high-purity, advanced pharmaceutical intermediate featuring a complex heterocyclic structure. This compound is of significant value for research and development in medicinal chemistry, particularly in the synthesis of targeted therapeutic agents. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing novel kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in oncology and other therapeutic areas.
• Kinase Inhibitor Research: Serves as a core scaffold or precursor for the development of potent and selective kinase inhibitors due to its pyridine and piperazine motifs.
• Medicinal Chemistry & SAR Studies: Used extensively in structure-activity relationship (SAR) studies to optimize drug potency, selectivity, and pharmacokinetic properties.
• Biochemical Assay Development: Employed as a reference standard or probe compound in high-throughput screening and biochemical assays.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for cutting-edge research in chemical biology and drug discovery.

Basic Information

Product Name	5-Bromo-1-Methyl-3-(5-(4-Methylpiperazin-1-Yl)Pyridin-2-Ylamino)Pyridin-2(1H)-One
CAS No.	1178884-45-1
Molecular Formula	C16H19BrN6O
Molecular Weight	391.27 g/mol
Synonyms	5-Bromo-1-methyl-3-{[5-(4-methyl-1-piperazinyl)-2-pyridinyl]amino}-2(1H)-pyridinone; 5-Bromo-1-methyl-3-[(5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino]pyridin-2(1H)-one; 1178884-45-1; UNII-9K0U8UJ8QN; 9K0U8UJ8QN; CHEMBL3186665; BDBM50157857; AKOS025147194
EINECS	Contact for details

Quality Control

Our production of 5-Bromo-1-Methyl-3-(5-(4-Methylpiperazin-1-Yl)Pyridin-2-Ylamino)Pyridin-2(1H)-One adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or cGMP guidelines for non-clinical use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; therefore, containers should be kept sealed under inert atmosphere when not in use to prevent moisture uptake and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.