Description

1-(2,2-Difluoroethyl)-n-Methylpiperidin-4-Amine is a high-purity, advanced pharmaceutical intermediate featuring a difluoroethyl-substituted piperidine scaffold. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers engaged in the development of next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel drug candidates, especially for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its unique difluoroethyl and amine functionalities.
• API Synthesis: Serves as a crucial building block in the multi-step synthesis of complex target molecules for preclinical and clinical trials.
• Biochemical Tool Compound: Employed in pharmacological assays and as a reference standard in analytical method development.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	1-(2,2-Difluoroethyl)-n-Methylpiperidin-4-Amine
CAS No.	1178346-64-9
Molecular Formula	C8H16F2N2
Molecular Weight	178.23 g/mol
Synonyms	N-Methyl-1-(2,2-difluoroethyl)piperidin-4-amine; 4-Amino-1-(2,2-difluoroethyl)-N-methylpiperidine; 1-(2,2-Difluoroethyl)-N-methyl-4-piperidinamine; N-Methyl-4-piperidinamine, 1-(2,2-difluoroethyl)-; 1178346-64-9
EINECS	Contact for details

Quality Control

Our 1-(2,2-Difluoroethyl)-n-Methylpiperidin-4-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with client specifications and relevant industry guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.