Description

1-(N-(2,2,2-Trifluoroethyl)Sulfamoyl)Piperidine-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique trifluoroethyl sulfamoyl piperidine scaffold. This compound is critical for medicinal chemistry research and development, offering a versatile building block for the synthesis of novel bioactive molecules. It is primarily sought by pharmaceutical R&D teams and fine chemical manufacturers focused on developing new therapeutic agents, particularly in areas requiring fluorinated motifs for enhanced metabolic stability and binding affinity.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and metabolic disease targets.
• Medicinal Chemistry Building Block: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to introduce the sulfamoyl and trifluoroethyl pharmacophores.
• Protease Inhibitor Research: Serves as a core structure or precursor in the design of inhibitors for various protease enzymes.
• Chemical Biology Probes: Utilized in the development of chemical probes to study enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of candidate drugs under cGMP conditions.
• Academic Research: Used in university and institutional labs for exploratory synthetic chemistry and drug discovery projects.

Basic Information

Product Name	1-(N-(2,2,2-Trifluoroethyl)Sulfamoyl)Piperidine-3-Carboxylic Acid
CAS No.	1178275-82-5
Molecular Formula	C9H13F3N2O4S
Molecular Weight	302.27 g/mol
Synonyms	1-[(2,2,2-Trifluoroethyl)sulfamoyl]piperidine-3-carboxylic acid; 3-Piperidinecarboxylic acid, 1-[[(2,2,2-trifluoroethyl)amino]sulfonyl]-; 1-((2,2,2-Trifluoroethyl)sulfamoyl)piperidine-3-carboxylic acid; Piperidine-3-carboxylic acid, 1-[(2,2,2-trifluoroethyl)sulfamoyl]-; 1178275-82-5; 1-(N-(2,2,2-Trifluoroethyl)sulfamoyl)piperidine-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 1-(N-(2,2,2-Trifluoroethyl)Sulfamoyl)Piperidine-3-Carboxylic Acid adheres to stringent quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure compliance with research-grade and cGMP-starting material standards. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.