Description

5-(Methoxycarbonyl)-5-Methyl-2-(3-Pyridinyl)-3-Pyrrolidinecarboxylic Acid Dihydrochloride is a high-purity, non-natural amino acid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical chiral building block and intermediate for the synthesis of complex, biologically active molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of new therapeutic agents, particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and other targeted therapies.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries in structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry Development: Serves as a starting material or intermediate in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing.
• Peptidomimetic Design: Employed in the design and synthesis of peptide analogs and mimetics due to its constrained pyrrolidine carboxylic acid structure.
• Asymmetric Synthesis: Utilized as a source of chirality in catalytic and stoichiometric asymmetric transformations to introduce stereocenters.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in API manufacturing.

Basic Information

Product Name	5-(Methoxycarbonyl)-5-Methyl-2-(3-Pyridinyl)-3-Pyrrolidinecarboxylic Acid Dihydrochloride
CAS No.	1177765-79-5
Molecular Formula	C14H17N2O4 · 2HCl
Molecular Weight	349.21 g/mol (Free base: 277.30 g/mol)
Synonyms	5-Methoxycarbonyl-5-methyl-2-(3-pyridyl)-3-pyrrolidinecarboxylic acid dihydrochloride; 2-(Pyridin-3-yl)-5-(methoxycarbonyl)-5-methylpyrrolidine-3-carboxylic acid dihydrochloride; (3S,5R)-5-Methoxycarbonyl-5-methyl-2-(pyridin-3-yl)pyrrolidine-3-carboxylic acid hydrochloride; (3R,5S)-5-Methoxycarbonyl-5-methyl-2-(3-pyridinyl)-3-pyrrolidinecarboxylic acid dihydrochloride; 1177765-79-5; Pyrrolidine-3-carboxylic acid, 5-(methoxycarbonyl)-5-methyl-2-(3-pyridinyl)-, dihydrochloride
EINECS	Contact for details

Quality Control

Our 5-(Methoxycarbonyl)-5-Methyl-2-(3-Pyridinyl)-3-Pyrrolidinecarboxylic Acid Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing identity, purity (HPLC), chiral purity, and impurity profile is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.