Description

[1-(2,4-Dichloro-Benzenesulfonyl)-Piperidin-2-Yl]-Methanol is a high-purity, advanced pharmaceutical intermediate characterized by its distinct benzenesulfonyl-piperidine scaffold. This compound matters for its critical role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. Pharmaceutical R&D teams and fine chemical manufacturers need it to develop new drug candidates targeting a range of diseases, leveraging its unique chemical structure to introduce specific pharmacological properties.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of potential new chemical entities (NCEs) for drug discovery programs.
• API Synthesis: Used as a building block for constructing complex molecules in the development of active pharmaceutical ingredients, especially those with sulfonamide and piperidine motifs.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead compounds in preclinical research.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for the cGMP production of clinical trial materials and commercial APIs.
• Biochemical Tool Compound: May be utilized in biochemical assays and as a reference standard for analytical method development and validation.

Basic Information

Product Name	[1-(2,4-Dichloro-Benzenesulfonyl)-Piperidin-2-Yl]-Methanol
CAS No.	1177643-98-9
Molecular Formula	C12H15Cl2NO3S
Molecular Weight	324.22 g/mol
Synonyms	1-[(2,4-Dichlorophenyl)sulfonyl]-2-piperidinemethanol; 2-Piperidinemethanol, 1-[(2,4-dichlorophenyl)sulfonyl]-; (1-((2,4-Dichlorophenyl)sulfonyl)piperidin-2-yl)methanol; 1-(2,4-Dichlorobenzenesulfonyl)piperidin-2-ylmethanol; 1-(2,4-Dichloro-benzenesulfonyl)-piperidin-2-yl-methanol; 1177643-98-9; 1-(2,4-Dichlorophenylsulfonyl)-2-piperidinemethanol
EINECS	Contact for details

Quality Control

Our [1-(2,4-Dichloro-Benzenesulfonyl)-Piperidin-2-Yl]-Methanol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research. Each lot undergoes rigorous analytical testing, including HPLC for assay and purity, and is supported by a comprehensive Certificate of Analysis (COA). We adhere to ICH Q7 guidelines for active pharmaceutical ingredients, and our quality commitment ensures the material meets the stringent requirements for use in advanced synthesis and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 98.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.