Description

2-{[3-Chloro-5-(Trifluoromethyl)Pyridin-2-Yl]Sulfanyl}Ethan-1-Aminehydrochloride is a high-purity, advanced pharmaceutical intermediate with a distinct molecular architecture combining pyridine, trifluoromethyl, and thioether functionalities. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted bioactivity. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing next-generation small molecule drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, especially in oncology, CNS disorders, and anti-infective therapies.
• Agrochemical Synthesis: Serves as a precursor in the manufacture of advanced pesticides and herbicides, leveraging the biological activity of the pyridine and trifluoromethyl groups.
• Chemical Research & Development: Used in academic and industrial R&D for exploring novel heterocyclic compounds and structure-activity relationships (SAR).
• Ligand & Catalyst Preparation: Potential utility in the synthesis of specialized ligands for catalysis or in material science applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	2-{[3-Chloro-5-(Trifluoromethyl)Pyridin-2-Yl]Sulfanyl}Ethan-1-Aminehydrochloride
CAS No.	1177351-21-1
Molecular Formula	C8H9ClF3N2S • HCl
Molecular Weight	299.59 g/mol
Synonyms	2-[(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)thio]ethanamine hydrochloride; 2-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)thio)ethan-1-amine hydrochloride; 2-[(3-Chloro-5-(trifluoromethyl)-2-pyridinyl)thio]ethylamine hydrochloride; 2-Aminoethyl 3-chloro-5-(trifluoromethyl)pyridin-2-yl sulfide hydrochloride; 1177351-21-1; 2-({3-Chloro-5-[(trifluoromethyl)pyridin-2-yl]sulfanyl})ethanamine HCl
EINECS	Contact for details

Quality Control

Our 2-{[3-Chloro-5-(Trifluoromethyl)Pyridin-2-Yl]Sulfanyl}Ethan-1-Aminehydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Production can be aligned with cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.