Description

1-[(1-Methyl-1H-Pyrrol-2-Yl)Methyl]-4-Piperidinecarboxylic Acid(Saltdata: 1.2H2O) is a high-purity, non-racemic piperidine derivative of significant interest in advanced organic synthesis. This compound serves as a critical chiral building block and pharmacophore intermediate for the development of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and process chemistry of central nervous system (CNS) agents, receptor modulators, and other therapeutic candidates.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of complex drug molecules targeting neurological and psychiatric disorders.
• Chemical Research & Development: Used as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry: Employed in the scale-up and route development for the commercial manufacturing of APIs.
• Asymmetric Synthesis: Serves as a valuable starting material or intermediate for constructing enantiomerically pure compounds.
• Ligand & Catalyst Development: Potential use in the design of novel chiral ligands for catalytic asymmetric transformations.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and regulatory filings.

Basic Information

Product Name	1-[(1-Methyl-1H-Pyrrol-2-Yl)Methyl]-4-Piperidinecarboxylic Acid(Saltdata: 1.2H2O)
CAS No.	1177281-06-9
Molecular Formula	C13H20N2O2 • 1.2H2O
Molecular Weight	Approx. 248.33 (Anhydrous basis: 236.31)
Synonyms	4-Piperidinecarboxylic acid, 1-[(1-methyl-1H-pyrrol-2-yl)methyl]-, hydrate (1:1.2); 1-[(1-Methyl-1H-pyrrol-2-yl)methyl]piperidine-4-carboxylic acid hydrate; (R/S)-1-((1-Methyl-1H-pyrrol-2-yl)methyl)piperidine-4-carboxylic acid; 1-[(1-Methylpyrrol-2-yl)methyl]isonipecotic acid; NSC 796372 (hydrate form); A piperidine-pyrrole hybrid carboxylic acid.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols. Every batch undergoes comprehensive analytical characterization, including HPLC for chiral purity and chemical assay, NMR for structural confirmation, and KF titration for water content. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, ensuring compliance with the rigorous standards required for pharmaceutical R&D and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0% (Anhydrous basis)
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (Enantiomer-specific grades available)
Water Content (KF)	7.0% - 10.0% (Theoretical for 1.2 H2O: ~9.1%)
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.