Description

9-Benzyl-3,9-Diazaspiro[5.5]Undecane-2,4-Dione (Hydrochloride) is a high-purity, advanced pharmaceutical intermediate with a complex spirocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and receptor-targeted therapies. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those targeting neurological pathways.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing spirocyclic compounds in drug discovery programs.
• Process Chemistry Development: Used in the scale-up and optimization of synthetic routes for new chemical entities (NCEs).
• Reference Standard: Employed as an analytical standard for quality control and method validation in API manufacturing.
• Biochemical Research: Investigated for its potential activity in biochemical assays and as a tool compound.
• Custom Synthesis: A starting material for the contract manufacturing of specialized fine chemicals and bespoke molecules.

Basic Information

Product Name	9-Benzyl-3,9-Diazaspiro[5.5]Undecane-2,4-Dione (Hydrochloride)
CAS No.	1176981-07-9
Molecular Formula	C16H20N2O2 • HCl
Molecular Weight	308.80 g/mol (Free base: 272.34 g/mol)
Synonyms	9-Benzyl-3,9-diazaspiro[5.5]undecane-2,4-dione hydrochloride; 9-Benzyl-3,9-diazaspiro[5.5]undecane-2,4-dione HCl; 2,4-Dioxo-9-benzyl-3,9-diazaspiro[5.5]undecane hydrochloride; 3,9-Diazaspiro[5.5]undecane-2,4-dione, 9-benzyl-, hydrochloride; BDU Hydrochloride; Spirocyclic diketopiperazine derivative
EINECS	Contact for details

Quality Control

Our 9-Benzyl-3,9-Diazaspiro[5.5]Undecane-2,4-Dione (Hydrochloride) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure compliance with pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.