Description

4-Dimethylaminopyridine-2-Carboxylic Acid Hydrochloride is a high-purity, functionalized pyridine derivative that serves as a valuable intermediate and catalyst in advanced organic synthesis. Its significance lies in its dual functionality, combining the nucleophilic catalytic properties of the dimethylaminopyridine (DMAP) moiety with a carboxylic acid group for further derivatization. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel active ingredients or fine-tune reaction pathways.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug molecules, particularly those requiring a functionalized pyridine core.
• Catalyst/Co-catalyst: Utilized in acylation, esterification, and other nucleophilic catalysis reactions where its modified structure offers advantages over standard DMAP.
• Agrochemical Synthesis: Intermediate for creating novel herbicides, fungicides, and insecticides with tailored properties.
• Ligand Precursor: Serves as a starting material for the preparation of specialized ligands used in metal-catalyzed cross-coupling reactions.
• Polymer Chemistry: Monomer or additive for producing functional polymers with specific chemical or physical characteristics.
• Academic & R&D: Critical reagent in research laboratories for methodological development and exploring new synthetic routes.

Basic Information

Product Name	4-Dimethylaminopyridine-2-Carboxylic Acid Hydrochloride
CAS No.	1176419-71-8
Molecular Formula	C8H11N2O2·HCl
Molecular Weight	202.65 g/mol (Free base: 166.19 g/mol)
Synonyms	2-Carboxy-4-(dimethylamino)pyridine hydrochloride; 4-(Dimethylamino)picolinic acid hydrochloride; DMAP-2-COOH·HCl; 4-DMAP-2-carboxylic acid HCl; 2-Pyridinecarboxylic acid, 4-(dimethylamino)-, hydrochloride (1:1); 4-(N,N-Dimethylamino)pyridine-2-carboxylic acid hydrochloride
EINECS	Contact for details

Quality Control

Our 4-Dimethylaminopyridine-2-Carboxylic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the high standards required for research and industrial synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.