Description

9-(4-Methylbenzyl)-9,10-Dihydro-8H-Spiro[Chromeno[8,7-E][1,3]Oxazine-2,1'-Cyclohexan]-4(3H)-One is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic and chromeno-oxazine fused ring structure. This compound is of significant commercial interest for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of new chemical entities.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders or other specialized therapeutic areas.
• Organic Synthesis Building Block: Used in academic and industrial R&D for constructing complex heterocyclic frameworks due to its unique spirocyclic and fused ring system.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs to develop new pharmacophores.
• Process Chemistry Development: Integral to scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Reference Standard: Supplied as a high-purity standard for analytical method development, validation, and quality control in API manufacturing.

Basic Information

Product Name	9-(4-Methylbenzyl)-9,10-Dihydro-8H-Spiro[Chromeno[8,7-E][1,3]Oxazine-2,1'-Cyclohexan]-4(3H)-One
CAS No.	1175783-58-0
Molecular Formula	C25H27NO3
Molecular Weight	389.49 g/mol
Synonyms	9-(4-Methylbenzyl)-9,10-dihydro-8H-spiro[chromeno[8,7-e][1,3]oxazine-2,1'-cyclohexan]-4(3H)-one; 9-(p-Methylbenzyl)-9,10-dihydro-8H-spiro[chromeno[8,7-e][1,3]oxazine-2,1'-cyclohexan]-4(3H)-one; Spiro[chromeno[8,7-e][1,3]oxazine-2,1'-cyclohexane] derivative; CAS 1175783-58-0; 9-(4-Methylbenzyl)dihydrospiro[chromeno[8,7-e][1,3]oxazine-2,1'-cyclohexan]-4(3H)-one
EINECS	Contact for details

Quality Control

Our production of 9-(4-Methylbenzyl)-9,10-Dihydro-8H-Spiro[Chromeno[8,7-E][1,3]Oxazine-2,1'-Cyclohexan]-4(3H)-One adheres to stringent quality management systems, ensuring batch-to-batch consistency and high purity suitable for pharmaceutical R&D. Each lot undergoes comprehensive analytical testing, including HPLC purity assay, identity confirmation (IR, NMR), and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed to protect the product from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.