Description

2-(Triisopropylsilyl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiazole is a high-value, organoboron building block featuring both a thiazole heterocycle and a protected boronic ester functional group. This compound matters as a critical intermediate in modern synthetic chemistry, enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions. It is primarily needed by pharmaceutical R&D teams, agrochemical manufacturers, and advanced material scientists for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing thiazole cores.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific heterocyclic structures.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and organic semiconductors.
• Cross-Coupling Reactions: Essential reagent in palladium-catalyzed Suzuki-Miyaura couplings for the efficient formation of biaryl and other C-C bonds.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and labeled compounds for biological target identification and study.
• Ligand & Catalyst Development: Acts as a starting material for synthesizing novel ligands and organometallic catalysts.

Basic Information

Item	Details
Product Name	2-(Triisopropylsilyl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiazole
CAS No.	1175534-91-4
Molecular Formula	C19H36BNO2SSi
Molecular Weight	381.46 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(triisopropylsilyl)thiazole; 2-TIPS-5-BPin Thiazole; 2-(Triisopropylsilyl)thiazole-5-boronic acid pinacol ester; Thiazole-5-boronic acid, 2-(triisopropylsilyl)-, pinacol ester; TIPS-Thiazole-BPin; CAS 1175534-91-4
EINECS	Contact for details

Quality Control

Our 2-(Triisopropylsilyl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (H-NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.