Description

1'H-Spiro[Piperidine-4,3'-Quinolin]-2'(4'H)-One Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a complex spirocyclic structure. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of novel therapeutic agents. It is primarily sought after by R&D teams and process chemists in the pharmaceutical, biotechnology, and fine chemical industries for building complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of potential drug candidates targeting central nervous system (CNS) disorders, oncology, and other therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its unique spiro[piperidine-quinoline] scaffold.
• Chemical Biology Probe Development: Serves as a core structure for developing tool compounds to study biological pathways and protein function.
• Process Development & Scale-Up: Employed in route scouting and optimization for the commercial-scale production of active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for synthetic methodology development and exploring new chemical spaces.
• Custom Synthesis & Contract Manufacturing: A critical component for CDMOs (Contract Development and Manufacturing Organizations) offering bespoke synthesis services for client projects.

Basic Information

Product Name	1'H-Spiro[Piperidine-4,3'-Quinolin]-2'(4'H)-One Hydrochloride
CAS No.	1175358-24-3
Molecular Formula	C₁₃H₁₅ClN₂O
Molecular Weight	250.72 g/mol
Synonyms	1'H-Spiro(piperidine-4,3'-quinolin)-2'(4'H)-one hydrochloride; Spiro[piperidine-4,3'-quinoline]-2'(1'H)-one hydrochloride; 2'-Oxo-1',4'-dihydrospiro[piperidine-4,3'-quinoline] hydrochloride; 1'H-Spiro[piperidine-4,3'-quinoline]-2'(4'H)-one HCl; 1175358-24-3; UNII-8I3Q1Z5F4K; 8I3Q1Z5F4K
EINECS	Contact for details

Quality Control

Our production of 1'H-Spiro[Piperidine-4,3'-Quinolin]-2'(4'H)-One Hydrochloride adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with client specifications and supporting regulatory filings. Our quality system is designed to meet the exacting standards of pharmaceutical R&D and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere or with desiccant for long-term preservation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.