Description

1-(1,4-Dioxa-Spiro[4.5]Dec-8-Yl)-4-Iodo-1H-Pyrazole is a high-value, heterocyclic organic building block featuring a fused spirocyclic and pyrazole structure. This compound is critical for advanced research and development, particularly in pharmaceutical chemistry, where it serves as a versatile intermediate for constructing complex molecular architectures. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders or requiring spirocyclic motifs.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its unique three-dimensional scaffold and reactive iodine handle.
• Agrochemical Development: Employed in the discovery of new herbicides, fungicides, and insecticides where the pyrazole core is a common bioactive moiety.
• Cross-Coupling Reactions: The aryl iodide functional group makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira, Heck) to create diverse chemical libraries.
• Ligand and Catalyst Synthesis: Utilized for the preparation of specialized N-heterocyclic ligands for catalysis or metal-organic frameworks (MOFs).
• Material Science Research: Investigated as a precursor for organic electronic materials or photoactive compounds.

Basic Information

Product Name	1-(1,4-Dioxa-Spiro[4.5]Dec-8-Yl)-4-Iodo-1H-Pyrazole
CAS No.	1175275-29-2
Molecular Formula	C11H15IN2O2
Molecular Weight	334.16 g/mol
Synonyms	4-Iodo-1-(1,4-dioxaspiro[4.5]dec-8-yl)-1H-pyrazole; 1-(1,4-Dioxaspiro[4.5]decan-8-yl)-4-iodo-1H-pyrazole; 1H-Pyrazole, 1-(1,4-dioxaspiro[4.5]dec-8-yl)-4-iodo-; 4-Iodo-1-(1,4-dioxa-spiro[4.5]dec-8-yl)-1H-pyrazole; 1175275-29-2; Spirocyclic iodopyrazole intermediate
EINECS	Contact for details

Quality Control

Our 1-(1,4-Dioxa-Spiro[4.5]Dec-8-Yl)-4-Iodo-1H-Pyrazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your most sensitive R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep the container tightly sealed when not in use to prevent any potential contamination or degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.