Description

δ-5(6)-Norethindrone Acetate is a high-purity synthetic steroid intermediate of significant importance in pharmaceutical manufacturing. This compound serves as a critical precursor in the synthesis of various progestogen-based active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical companies engaged in the development and production of hormonal therapies and other specialized steroid-based drugs.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of advanced progestogen APIs and other steroid derivatives.
• Hormone Research: Used as a reference standard and starting material in biochemical and pharmacological research focused on steroid hormone action and receptor binding studies.
• Process Development: Employed in the development and optimization of novel synthetic routes for steroid-based pharmaceuticals within R&D laboratories.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of final drug substances.

Basic Information

Product Name	δ-5(6)-Norethindrone Acetate
CAS No.	1175129-26-6
Molecular Formula	C22H28O3
Molecular Weight	340.46 g/mol
Synonyms	19-Nor-17α-pregn-5(6)-en-20-yn-3β-ol, 17-acetate; 3β-Hydroxy-19-nor-17α-pregn-5(6)-en-20-yn-17-yl acetate; 17α-Ethynyl-19-norandrost-5(6)-en-3β-ol, 17-acetate; δ5(6)-19-Norethisterone Acetate; 5(6)-Dehydronorethindrone Acetate; Norethindrone Acetate δ-5(6) Isomer
EINECS	Contact for details

Quality Control

Our δ-5(6)-Norethindrone Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by spectroscopic methods (IR, NMR), to ensure it meets exacting standards suitable for pharmaceutical R&D and intermediate use. Certificates of Analysis (COA) with batch-specific data are provided.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.