Description

Dmaba-D6 Nhs Ester CAS NO 1175002-04-6 is a deuterated, amine-reactive labeling reagent designed for advanced proteomics and metabolomics research. This compound is critical for introducing stable isotope tags into biomolecules, enabling highly accurate quantitative mass spectrometry analysis. It is primarily utilized by research institutions and pharmaceutical companies engaged in biomarker discovery, drug metabolism studies, and protein interaction mapping.

Application

• Quantitative Proteomics: Used as an active ester reagent for stable isotope labeling of peptides and proteins for LC-MS/MS quantification.
• Biomarker Discovery: Enables comparative analysis of protein expression levels in disease versus healthy tissue samples.
• Metabolomics Research: Serves as a derivatization agent for the quantification of amine-containing metabolites.
• Chemical Biology: Facilitates the site-specific modification of proteins and antibodies for functional studies.
• Drug Development: Applied in pharmacokinetic (PK) and pharmacodynamic (PD) studies to track and quantify drug molecules and their metabolites.
• Diagnostic Assay Development: Used in the synthesis of internal standards for mass spectrometry-based clinical diagnostics.

Basic Information

Product Name	Dmaba-D6 Nhs Ester
CAS No.	1175002-04-6
Molecular Formula	C13H7D6NO4
Molecular Weight	Contact for details
Synonyms	4-(Dimethylamino-d6)benzoic Acid N-Hydroxysuccinimide Ester; Dmaba-D6 NHS Ester; N-Succinimidyl 4-(Dimethylamino-d6)benzoate; N-Hydroxysuccinimide Ester of Dmaba-D6; Deuterated NHS-Dmaba; 4-(N,N-Dimethyl-d6-amino)benzoic Acid NHS Ester; Succinimidyl 4-(Dimethyl-d6-amino)benzoate; D6-Dmaba-OSu
EINECS	Contact for details

Quality Control

Our Dmaba-D6 Nhs Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and isotopic enrichment, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) detailing batch-specific results are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC-MS)	Conforms
Purity (HPLC)	≥ 95%
Isotopic Enrichment (D)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.