Description

4-Ethynyl-1H-Pyrrolo[2,3-B]Pyridine is a high-value heterocyclic building block featuring a fused pyrrolopyridine core with a terminal ethynyl group, enabling versatile cross-coupling and click chemistry reactions. This compound is essential for medicinal chemistry research and development, serving as a key precursor in the synthesis of targeted small molecule inhibitors. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers working on kinase inhibitors and other biologically active compounds.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel kinase inhibitors and other targeted therapeutics.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns for constructing complex molecular architectures.
• Bioconjugation & Probe Development: The terminal alkyne group facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAC) for labeling and probe synthesis.
• Chemical Biology: Employed in the development of chemical tools and molecular probes for studying biological pathways.
• Material Science Precursor: Potential use in creating organic electronic materials and metal-organic frameworks (MOFs) due to its conjugated system.
• Custom Synthesis: Serves as a starting material for contract research organizations (CROs) and CDMOs for client-specific projects.

Basic Information

Product Name	4-Ethynyl-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	1174297-28-9
Molecular Formula	C9H6N2
Molecular Weight	142.16 g/mol
Synonyms	4-Ethynyl-1H-pyrrolo[2,3-b]pyridine; 4-Ethynyl-7-azaindole; 1H-Pyrrolo[2,3-b]pyridine, 4-ethynyl-; 4-Ethynyl-1H-pyrrolo[2,3-b]pyridine; 4-Ethynyl-7-aza-indole; 4-Ethynyl-7-azaindole; 7-Azaindole, 4-ethynyl-
EINECS	Contact for details

Quality Control

Our 4-Ethynyl-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural identity. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with client specifications and supporting regulatory filings for research use.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label or COA. The material is easily oxidized and light-sensitive. Keep container tightly sealed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.