Description

Propargyl-Succinimidyl-Ester CAS NO 1174157-65-3 is a high-purity, functionalized chemical building block designed for advanced bioconjugation and click chemistry applications. Its core value lies in the succinimidyl ester group, which enables efficient and selective amide bond formation with primary amines, and the propargyl group, which facilitates subsequent copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions. This bifunctional reagent is essential for researchers and manufacturers in pharmaceutical development, proteomics, and materials science who require reliable, site-specific labeling and crosslinking of biomolecules and polymers.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: Site-specific labeling of proteins, antibodies, and peptides for therapeutic and diagnostic applications.
• Proteomics Research: Functionalization of surfaces and beads for affinity purification, pull-down assays, and mass spectrometry sample preparation.
• Polymer and Materials Science: Synthesis of functionalized polymers, hydrogels, and dendrimers via click chemistry for advanced material properties.
• Diagnostic Reagent Manufacturing: Conjugation of enzymes, fluorophores, or other reporter molecules to detection probes for ELISA and lateral flow assays.
• Chemical Biology Tool Development: Creation of activity-based probes and affinity labels for studying enzyme function and metabolic pathways.
• Nanoparticle Functionalization: Surface modification of quantum dots, liposomes, and other nanoparticles for targeted delivery and imaging.

Basic Information

Product Name	Propargyl-Succinimidyl-Ester
CAS No.	1174157-65-3
Molecular Formula	C9H9NO4
Molecular Weight	195.17 g/mol
Synonyms	N-Hydroxysuccinimide Propargyl Ester; Propargyl NHS Ester; NHS-Propargyl; 2,5-Dioxopyrrolidin-1-yl prop-2-ynoate; Propiolic Acid N-Hydroxysuccinimide Ester; Propargyloxycarbonyl NHS Ester; Click Chemistry Reagent NHS-Ester; Alkyne Functionalized NHS Ester
EINECS	Contact for details

Quality Control

Our Propargyl-Succinimidyl-Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high performance. Each lot undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and FTIR for functional group verification. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent hydrolysis of the active ester group. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.