Description

tert-Butyl 3-(Tetramethyl-1,3,2-Dioxaborolan-2-yl)-1H-pyrrolo[2,3-c]pyridine-1-carboxylate is a high-purity, protected boronic ester derivative of a pyrrolopyridine heterocycle, serving as a critical synthetic intermediate. Its value lies in providing a stable, reactive handle for advanced cross-coupling reactions, enabling the efficient construction of complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries engaged in the development of novel active ingredients, particularly for targeted therapies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other small-molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling: Used as a boronic ester coupling partner to introduce the pyrrolo[2,3-c]pyridine moiety into complex molecules under palladium catalysis.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies and the exploration of new chemical space in drug discovery programs.
• Agrochemical Synthesis: Employed in the research and development of novel herbicides, fungicides, and insecticides.
• Material Science Precursor: Potential use in the synthesis of organic electronic materials and ligands for catalysis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and advanced intermediates at various scales.

Basic Information

Product Name	tert-Butyl 3-(Tetramethyl-1,3,2-Dioxaborolan-2-yl)-1H-pyrrolo[2,3-c]pyridine-1-carboxylate
CAS No.	1174038-67-5
Molecular Formula	C18H25BN2O4
Molecular Weight	344.22 g/mol
Synonyms	1-Boc-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-c]pyridine; tert-Butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-c]pyridine-1-carboxylate; 1H-Pyrrolo[2,3-c]pyridine-1-carboxylic acid, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1-dimethylethyl ester; 3-Boronic acid, 1H-pyrrolo[2,3-c]pyridine-1-carboxylic acid 1,1-dimethylethyl ester, pinacol ester; 1-Boc-3-pinacolboron pyrrolo[2,3-c]pyridine
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(Tetramethyl-1,3,2-Dioxaborolan-2-yl)-1H-pyrrolo[2,3-c]pyridine-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP and ICH Q7 guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.