Description

tert-Butyl (3S,4S)-3-Fluoro-4-Hydroxypiperidine-1-Carboxylate is a high-purity, chiral piperidine derivative serving as a critical building block in modern pharmaceutical synthesis. This compound is valued for its unique stereochemistry and fluorine substitution, which are essential for modulating the biological activity, metabolic stability, and physicochemical properties of drug candidates. It is primarily sought after by research and development teams in the pharmaceutical and biotechnology sectors for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and commercial-scale synthesis of complex drug molecules.
• API Development: Used to construct the core piperidine scaffold in new chemical entities (NCEs) for preclinical and clinical studies.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies by introducing fluorine and hydroxyl functional groups at specific stereocenters.
• Process Chemistry: Serves as a starting material or advanced intermediate in the development of robust and scalable manufacturing routes for APIs.
• Bioconjugation & Probe Synthesis: Potential use in creating labeled compounds or molecular probes for biochemical research.

Basic Information

Product Name	tert-Butyl (3S,4S)-3-Fluoro-4-Hydroxypiperidine-1-Carboxylate
CAS No.	1174020-44-0
Molecular Formula	C10H18FNO3
Molecular Weight	219.26 g/mol
Synonyms	1-Boc-3-fluoro-4-hydroxypiperidine (3S,4S)-; (3S,4S)-1-(tert-Butoxycarbonyl)-3-fluoro-4-hydroxypiperidine; (3S,4S)-3-Fluoro-4-hydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl (3S,4S)-3-fluoro-4-hydroxypiperidine-1-carboxylate; (3S,4S)-3-Fluoro-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester; 1-N-Boc-(3S,4S)-3-fluoro-4-hydroxypiperidine; Boc-(3S,4S)-3-Fluoro-4-hydroxypiperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl (3S,4S)-3-Fluoro-4-Hydroxypiperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for demanding pharmaceutical applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and compliance with your research or cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.