Description

tert-Butyl 1-Cyano-6-Azaspiro[2.5]Octane-6-Carboxylate is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic and cyano-substituted structure. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for constructing complex bioactive molecules. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing novel therapeutics, particularly in areas like central nervous system (CNS) and oncology drug discovery.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting complex biological pathways.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities with potential therapeutic effects.
• Proteolysis Targeting Chimera (PROTAC) Development: The spirocyclic and cyano motifs make it a valuable component in the design of heterobifunctional degraders.
• CNS Drug Discovery: Employed in the research and synthesis of compounds intended to cross the blood-brain barrier for neurological and psychiatric indications.
• Chemical Biology Probes: Serves as a scaffold for creating tool compounds used to study enzyme function and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	tert-Butyl 1-Cyano-6-Azaspiro[2.5]Octane-6-Carboxylate
CAS No.	1174006-82-6
Molecular Formula	C13H20N2O2
Molecular Weight	236.31 g/mol
Synonyms	6-(tert-Butoxycarbonyl)-1-cyano-6-azaspiro[2.5]octane; 1-Cyano-6-azaspiro[2.5]octane-6-carboxylic acid tert-butyl ester; 6-Boc-1-cyano-6-azaspiro[2.5]octane; tert-Butyl 1-cyano-6-azaspiro[2.5]octane-6-carboxylate; 1-Cyano-6-azaspiro[2.5]octane-6-carboxylic acid 1,1-dimethylethyl ester; Boc-1-CN-6-azaspiro[2.5]octane; 6-Azaspiro[2.5]octane-6-carboxylic acid, 1-cyano-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 1-Cyano-6-Azaspiro[2.5]Octane-6-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.