Description

(R)-Methyl-6'-Hydroxy-8A'-Methyl-3',4',4A',5',8',8A'-Hexahydro-2'H-Spiro[1,3-Dioxolane-2,1'-Naphthalene]-7'-Carboxylate is a sophisticated chiral building block and advanced pharmaceutical intermediate characterized by its complex spirocyclic and hexahydronaphthalene structure. This compound is of significant value for the synthesis of high-potency active pharmaceutical ingredients (APIs) and other fine chemicals requiring precise stereochemical control. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors engaged in developing novel therapeutic agents and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly in steroid-like or complex polycyclic therapeutic areas.
• Asymmetric Synthesis: Serves as a critical starting material or intermediate in catalytic asymmetric synthesis and total synthesis projects requiring high enantiomeric purity.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new chemical entities.
• Agrochemical Development: Potential application as an intermediate in the synthesis of advanced, biologically active crop protection agents.
• Academic & Industrial R&D: Employed in chemical research laboratories for methodological development and the exploration of new synthetic pathways.
• Fine Chemical Production: Used in the custom synthesis of complex, high-value specialty chemicals for various industrial applications.

Basic Information

Product Name	(R)-Methyl-6'-Hydroxy-8A'-Methyl-3',4',4A',5',8',8A'-Hexahydr o-2'H-Spiro[1,3-Dioxolane-2,1'-Naphthalene]-7'-Carboxylate
CAS No.	1173666-68-6
Molecular Formula	C₁₇H₂₄O₅
Molecular Weight	308.37 g/mol
Synonyms	(6'R,8a'S)-Methyl 6'-hydroxy-8a'-methyl-1',2',3',4',4a',5',8',8a'-octahydrospiro[1,3-dioxolane-2,1'-naphthalene]-7'-carboxylate; Methyl (1'R,3aS',6'S,7a'S)-6'-hydroxy-7a'-methyl-octahydrospiro[1,3-dioxolane-2,1'-inden]-4'-carboxylate; (R)-Spiro-dioxolane-naphthalene carboxylate derivative; Advanced Steroidal Intermediate; Chiral Spirocyclic Ester; CAS 1173666-68-6
EINECS	Contact for details

Quality Control

Our production of this high-purity intermediate adheres to strict quality management systems. Each batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to ensure chemical identity, enantiomeric purity, and specified impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support development and commercial projects requiring compliance with cGMP and other relevant regulatory guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.