Description

Ethyl-(8A'R)-8A'-Methyl-6'-Oxo-3',4',6',7',8',8A'-Hexahydro-2'H-Spiro[1,3-Dioxolane-2,1'-Naphthalene]-5'-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic and decalin-fused structure. This compound is of significant value in organic synthesis, serving as a critical chiral building block for the development of novel active pharmaceutical ingredients (APIs). It is primarily needed by R&D chemists and process development teams within the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecular architectures with precise stereochemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of complex drug candidates, particularly those targeting neurological and metabolic disorders.
• Asymmetric Synthesis: Utilized as a sophisticated precursor for constructing stereochemically defined centers in natural product synthesis and medicinal chemistry.
• Agrochemical Research: Serves as a building block for developing new generation pesticides and herbicides with enhanced efficacy and selectivity.
• Fine Chemical Manufacturing: Employed in the custom synthesis of specialty chemicals, flavors, and fragrances requiring high stereochemical purity.
• Academic & Institutional R&D: Used in university and research institute laboratories for methodological studies in organic synthesis and catalysis.
• Process Chemistry Development: Acts as a model compound for scaling up and optimizing synthetic routes under current Good Manufacturing Practice (cGMP) guidelines.

Basic Information

Product Name	Ethyl-(8A'R)-8A'-Methyl-6'-Oxo-3',4',6',7',8',8A'-Hexahydro-2'H-Spiro[1,3-Dioxolane-2,1'-Naphthalene]-5'-Carboxylate
CAS No.	1173666-35-7
Molecular Formula	C₁₈H₂₆O₅
Molecular Weight	322.40 g/mol
Synonyms	Ethyl (8aR)-8a-methyl-6-oxo-3,4,6,7,8,8a-hexahydro-2H-spiro[1,3-dioxolane-2,1'-naphthalene]-5'-carboxylate; (8aR)-8a-Methyl-6'-oxo-3',4',6',7',8',8a'-hexahydro-2'H-spiro[1,3-dioxolane-2,1'-naphthalene]-5'-carboxylic acid ethyl ester; Spiro[1,3-dioxolane-2,1'(2'H)-naphthalene]-5'-carboxylic acid, 3',4',6',7',8',8a'-hexahydro-8a'-methyl-6'-oxo-, ethyl ester, (8a'R)-; Ethyl 8a-methyl-6-oxo-3,4,6,7,8,8a-hexahydro-2H-spiro[1,3-dioxolane-2,1-naphthalene]-5-carboxylate (stereoisomer); CAS 1173666-35-7
EINECS	Contact for details

Quality Control

Our Ethyl-(8A'R)-8A'-Methyl-6'-Oxo-3',4',6',7',8',8A'-Hexahydro-2'H-Spiro[1,3-Dioxolane-2,1'-Naphthalene]-5'-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with stringent industry standards for advanced intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.