Description

(R)-Spiro[1,3-Dioxolane-2,1'(2'H)-Naphthalene]-5'-Carboxylic Acid, 3',4',6',7',8',8'A-Hexahydro-8'A-Methyl-, Ethyl Ester (9Ci) is a high-purity, chiral spirocyclic compound serving as a sophisticated synthetic intermediate. This molecule matters for its defined stereochemistry and functional group architecture, enabling the precise construction of complex target molecules in advanced research and development. It is primarily needed by pharmaceutical, agrochemical, and specialty chemical R&D teams focused on developing novel active ingredients, catalysts, and functional materials.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides requiring specific stereochemical configurations for bioactivity.
• Catalyst & Ligand Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Investigated as a monomer or additive for developing polymers with unique optical or structural properties.
• Academic & Process Chemistry: Employed in university and industrial labs for methodological studies and scale-up process development of complex organic molecules.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring high stereochemical purity and reliable supply.

Basic Information

Item	Details
Product Name	(R)-Spiro[1,3-Dioxolane-2,1'(2'H)-Naphthalene]-5'-Carboxylic Acid, 3',4',6',7',8',8'A-Hexahydro-8'A-Methyl-, Ethyl Ester (9Ci)
CAS No.	1173664-74-8
Molecular Formula	C17H22O4
Molecular Weight	290.35 g/mol
Synonyms	(R)-Ethyl 8a-methyl-3,4,6,7,8,8a-hexahydrospiro[1,3-dioxolane-2,1'-naphthalene]-5'-carboxylate; (8aR)-Ethyl 8a-methyl-3,4,6,7,8,8a-hexahydro-2H-spiro[[1,3]dioxolane-2,1'-naphthalene]-5'-carboxylate; Ethyl (8aR)-8a-methyl-3,4,6,7,8,8a-hexahydro-2H-spiro[1,3-dioxolane-2,1'-naphthalene]-5'-carboxylate; (R)-Spiro[1,3-dioxolane-2,1'(2'H)-naphthalene]-5'-carboxylic acid, 3',4',6',7',8',8'a-hexahydro-8'a-methyl-, ethyl ester; CAS 1173664-74-8
EINECS	Contact for details

Quality Control

Our (R)-Spiro[1,3-Dioxolane-2,1'(2'H)-Naphthalene]-5'-Carboxylic Acid, 3',4',6',7',8',8'A-Hexahydro-8'A-Methyl-, Ethyl Ester (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard purity assays, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided and can be tailored to meet specific client requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive (store away from light) and should be handled in a dry environment to minimize moisture exposure. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.