Description

1-Ethoxycarbonyl-1-Tosylmethyl Isocyanide is a specialized organic building block featuring both an isocyanide and a tosylmethyl group. This compound matters for its versatility as a key reagent in multi-component reactions, enabling the efficient synthesis of complex heterocyclic scaffolds. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel molecular libraries and active ingredients.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of nitrogen-containing heterocycles like pyrroles, imidazoles, and oxazoles, which are core structures in many drug candidates.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides by creating diverse chemical space for biological screening.
• Material Science: Employed in the preparation of functional polymers and ligands for catalysis via its reactive isocyanide functionality.
• Academic & R&D: Serves as a valuable reagent in methodology development for novel multi-component reactions (MCRs) and isocyanide-based transformations.
• Chemical Library Synthesis: Facilitates the rapid generation of compound libraries for high-throughput screening in drug discovery programs.

Basic Information

Product Name	1-Ethoxycarbonyl-1-Tosylmethyl Isocyanide
CAS No.	1173149-43-3
Molecular Formula	C12H13NO4S
Molecular Weight	267.30 g/mol
Synonyms	Ethyl 2-Isocyano-2-(4-methylphenylsulfonyl)acetate; 2-Isocyano-2-tosylacetic Acid Ethyl Ester; 1-Tosylmethyl-1-ethoxycarbonyl Isocyanide; Tosylmethyl Isocyanide, Ethoxycarbonyl Derivative; TOSMIC Ethyl Ester Derivative; ETC-TosMIC; (Ethoxycarbonyl)(tosylmethyl)isocyanide; Ethyl (Isocyanato(p-tolylsulfonyl)methyl)formate
EINECS	Contact for details

Quality Control

Our 1-Ethoxycarbonyl-1-Tosylmethyl Isocyanide is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.