Description

1H-Pyrrolo[2,3-B]Pyridine, 5-Bromo-4-Fluoro-1-(Phenylsulfonyl)- is a high-purity, advanced pharmaceutical intermediate (API) featuring a halogenated pyrrolopyridine core, a privileged scaffold in modern drug discovery. This compound is specifically engineered to serve as a critical building block for the synthesis of novel, targeted small-molecule therapeutics. It is essential for research and development chemists in the pharmaceutical and biotechnology sectors working on kinase inhibitors, oncology treatments, and other precision medicines.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for kinase-targeted therapies.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) and improve drug-like properties.
• Oncology Drug Development: The pyrrolopyridine scaffold is prevalent in compounds designed to modulate specific cancer-related signaling pathways.
• Bioconjugation & Probe Synthesis: The reactive halogen and sulfonyl group offer handles for further functionalization, useful in creating chemical probes for biological studies.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up of novel chemical entities for clinical trials.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 5-Bromo-4-Fluoro-1-(Phenylsulfonyl)-
CAS No.	1172067-98-9
Molecular Formula	C13H8BrFN2O2S
Molecular Weight	355.18 g/mol
Synonyms	5-Bromo-4-fluoro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 5-Bromo-4-fluoro-1H-pyrrolo[2,3-b]pyridine 1-(phenylsulfonyl); 1-(Benzenesulfonyl)-5-bromo-4-fluoro-1H-pyrrolo[2,3-b]pyridine; 5-Bromo-4-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridine (common alias); 1172067-98-9; 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-4-fluoro-1-(phenylsulfonyl)-; 5-Bromo-4-fluoro-1H-pyrrolo[2,3-b]pyridine, 1-(phenylsulfonyl) derivative
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine, 5-Bromo-4-Fluoro-1-(Phenylsulfonyl)- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP guidelines for advanced intermediates used in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.