Description

tert-Butyl 2-((tert-Butyldimethylsilyloxy)Methyl)-Furo[3,2-B]Pyridin-6-Ylcarbamate is a high-value, protected heterocyclic building block designed for advanced organic synthesis. This compound is critical for researchers and process chemists requiring precise molecular scaffolds to construct complex pharmaceutical intermediates. It is primarily utilized in the research and development of novel active pharmaceutical ingredients (APIs), particularly within medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the multi-step synthesis of complex drug candidates, especially in oncology and antiviral research.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Process Chemistry Development: Employed in route scouting and scale-up studies for the production of advanced intermediates under GMP-like conditions.
• Kinase Inhibitor Synthesis: A crucial building block for constructing furo[3,2-b]pyridine cores found in various kinase inhibitor targets.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Academic Research: Used in university and institutional labs for methodological development in heterocyclic and organosilicon chemistry.

Basic Information

Product Name	tert-Butyl 2-((tert-Butyldimethylsilyloxy)Methyl)-Furo[3,2-B]Pyridin-6-Ylcarbamate
CAS No.	1171920-60-7
Molecular Formula	C20H32N2O4Si
Molecular Weight	392.57 g/mol
Synonyms	6-(((tert-Butoxy)carbonyl)amino)-2-(((tert-butyldimethylsilyl)oxy)methyl)furo[3,2-b]pyridine; tert-Butyl N-[2-[[(tert-butyldimethylsilyl)oxy]methyl]furo[3,2-b]pyridin-6-yl]carbamate; BOC-Protected Furo[3,2-b]pyridine TBDMS Ether; 6-(Boc-amino)-2-((TBDMS-oxy)methyl)furo[3,2-b]pyridine; TBDMS Ether of BOC-Furopyridine; (6-((tert-Butoxycarbonyl)amino)furo[3,2-b]pyridin-2-yl)methyl tert-butyldimethylsilyl ether; 1171920-60-7
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-((tert-Butyldimethylsilyloxy)Methyl)-Furo[3,2-B]Pyridin-6-Ylcarbamate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.