Description

2-((tert-Butyldimethylsilyloxy)Methyl)-6-((Trimethylsilyl)Ethynyl)Furo[3,2-B]Pyridine is a high-value, multi-functionalized heterocyclic building block designed for advanced synthetic chemistry. This compound is engineered to provide a protected, reactive scaffold that is critical for constructing complex molecular architectures, particularly in pharmaceutical research. It is an essential intermediate for medicinal chemists and process development scientists working in drug discovery, agrochemical development, and materials science.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of new crop protection agents and herbicides due to its functionalized furopyridine core.
• Material Science Research: Serves as a precursor for organic electronic materials, including organic light-emitting diodes (OLEDs) and semiconductors.
• Cross-Coupling Reactions: The ethynyl and silyl-protected groups make it an excellent substrate for Sonogashira, Suzuki, and other palladium-catalyzed cross-coupling reactions.
• Chemical Biology Probes: Utilized in the development of molecular probes and tags for studying biological systems and target engagement.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of complex target molecules.

Basic Information

Product Name	2-((tert-Butyldimethylsilyloxy)Methyl)-6-((Trimethylsilyl)Ethynyl)Furo[3,2-B]Pyridine
CAS No.	1171920-57-2
Molecular Formula	C20H31NO2Si2
Molecular Weight	373.64 g/mol
Synonyms	6-((Trimethylsilyl)ethynyl)-2-(((tert-butyldimethylsilyl)oxy)methyl)furo[3,2-b]pyridine; 2-(((tert-Butyldimethylsilyl)oxy)methyl)-6-((trimethylsilyl)ethynyl)furo[3,2-b]pyridine; TBDMS-protected furopyridine alkyne; Furo[3,2-b]pyridine-2-methanol, 6-[(trimethylsilyl)ethynyl]-, 2-(1,1-dimethylethyl)dimethylsilyl ether; TMS-Ethynyl Furopyridine TBDMS Ether
EINECS	Contact for details

Quality Control

Our 2-((tert-Butyldimethylsilyloxy)Methyl)-6-((Trimethylsilyl)Ethynyl)Furo[3,2-B]Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake, which can affect stability and reactivity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.