Description

2-((tert-Butyldimethylsilyloxy)Methyl)-Furo[3,2-B]Pyridine-6-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a protected hydroxymethyl group, which is critical for controlled synthesis in complex organic transformations. This compound matters because it provides a versatile and reactive scaffold for medicinal chemists, enabling the development of novel active pharmaceutical ingredients (APIs) with enhanced selectivity and potency. It is primarily needed by R&D laboratories and production facilities in the pharmaceutical and biotechnology sectors engaged in the synthesis of new drug candidates, particularly those targeting neurological and oncological pathways.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the multi-step synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic molecules.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Custom Synthesis: A critical starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.
• Bioconjugation & Prodrug Development: The carboxylic acid and protected alcohol functionalities allow for conjugation to carriers or the creation of prodrug formulations.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and target validation.

Basic Information

Product Name	2-((tert-Butyldimethylsilyloxy)Methyl)-Furo[3,2-B]Pyridine-6-Carboxylic Acid
CAS No.	1171920-49-2
Molecular Formula	C16H23NO4Si
Molecular Weight	321.45 g/mol
Synonyms	6-Carboxy-2-((tert-butyldimethylsilyloxy)methyl)furo[3,2-b]pyridine; Furo[3,2-b]pyridine-6-carboxylic acid, 2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-; 2-((TBDMSO)Methyl)furo[3,2-b]pyridine-6-carboxylic acid; 2-((tert-Butyldimethylsilanyloxy)methyl)-furo[3,2-b]pyridine-6-carboxylic acid; 2-(((tert-Butyldimethylsilyl)oxy)methyl)furo[3,2-b]pyridine-6-carboxylic acid; TBDMS-protected furopyridine carboxylic acid
EINECS	Contact for details

Quality Control

Our 2-((tert-Butyldimethylsilyloxy)Methyl)-Furo[3,2-B]Pyridine-6-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring the material is suitable for use in advanced pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.