Description

2-((tert-Butyldimethylsilyloxy)Methyl)-6-Chlorofuro[3,2-B]Pyridine CAS NO 1171920-42-5 is a high-value, multi-functional heterocyclic building block featuring both a protected hydroxymethyl group and a reactive chloro substituent. This compound is specifically engineered for advanced pharmaceutical research and development, serving as a critical intermediate in the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the construction of furopyridine-based drug candidates, particularly in oncology and CNS therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies due to its versatile reactive sites for further functionalization.
• Process Chemistry Development: Serves as a stable, protected intermediate in scalable route development for API manufacturing.
• Agrochemical Synthesis: Employed in the research and production of novel pesticides and herbicides that incorporate the furo[3,2-b]pyridine scaffold.
• Ligand and Catalyst Preparation: Useful for synthesizing specialized nitrogen-oxygen containing ligands for metal catalysis.
• Material Science Research: Potential building block for organic electronic materials and photoactive compounds.

Basic Information

Product Name	2-((tert-Butyldimethylsilyloxy)Methyl)-6-Chlorofuro[3,2-B]Pyridine
CAS No.	1171920-42-5
Molecular Formula	C15H22ClNO2Si
Molecular Weight	311.88 g/mol
Synonyms	6-Chloro-2-(((tert-butyldimethylsilyl)oxy)methyl)furo[3,2-b]pyridine; 2-(((tert-Butyldimethylsilyl)oxy)methyl)-6-chlorofuro[3,2-b]pyridine; 6-Chloro-2-((TBDMS-Oxy)methyl)furo[3,2-b]pyridine; TBDMS-protected 6-Chlorofuro[3,2-b]pyridine methanol; 6-Chloro-2-(hydroxymethyl)furo[3,2-b]pyridine TBDMS ether; 1171920-42-5; tert-Butyldimethyl((6-chlorofuro[3,2-b]pyridin-2-yl)methoxy)silane
EINECS	Contact for details

Quality Control

Our 2-((tert-Butyldimethylsilyloxy)Methyl)-6-Chlorofuro[3,2-B]Pyridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with ICH guidelines for impurities and can provide material suitable for use under cGMP conditions for non-clinical development stages upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under inert atmosphere when appropriate to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.