Description

2-((tert-Butyldimethylsilyloxy)Methyl)-Furo[3,2-B]Pyridine-6-Carbaldehyde is a high-purity, advanced pharmaceutical intermediate featuring a protected hydroxymethyl group and a reactive aldehyde functionality. This compound matters as a critical building block for medicinal chemists, enabling the synthesis of complex heterocyclic molecules with precise stereochemistry and functional group compatibility. It is primarily needed by R&D and process development teams in the pharmaceutical and biotechnology sectors for the development of new active pharmaceutical ingredients (APIs), particularly in oncology and antiviral research.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of novel drug candidates, especially those containing fused furopyridine scaffolds.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry Development: Serves as a standardized starting material for scaling up synthetic routes under GMP-like conditions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds for clinical trial materials.
• Chemical Biology Probes: The aldehyde group allows for conjugation, making it useful for creating labeled compounds or bioconjugates for target identification.
• Academic Research: Employed in university and institutional labs for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	2-((tert-Butyldimethylsilyloxy)Methyl)-Furo[3,2-B]Pyridine-6-Carbaldehyde
CAS No.	1171920-38-9
Molecular Formula	C16H23NO3Si
Molecular Weight	305.45 g/mol
Synonyms	6-Formyl-2-(((tert-butyldimethylsilyl)oxy)methyl)furo[3,2-b]pyridine; Furo[3,2-b]pyridine-6-carbaldehyde, 2-(((1,1-dimethylethyl)dimethylsilyl)oxy)methyl]-; TBDMS-protected furopyridine carbaldehyde; 2-((Tert-butyldimethylsilyloxy)methyl)furo[3,2-b]pyridine-6-carboxaldehyde; 2-(((tert-Butyldimethylsilyl)oxy)methyl)furo[3,2-b]pyridine-6-carbaldehyde; 1171920-38-9; 2-[(tert-Butyldimethylsilyloxy)methyl]furo[3,2-b]pyridine-6-carbaldehyde
EINECS	Contact for details

Quality Control

Our 2-((tert-Butyldimethylsilyloxy)Methyl)-Furo[3,2-B]Pyridine-6-Carbaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with ICH guidelines, supporting its use in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated place, separate from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.