Description

6-Bromo-2-((tert-Butyldimethylsilyloxy)Methyl)-Furo[3,2-B]Pyridine is a high-value, advanced pharmaceutical intermediate featuring a fused furopyridine core protected by a tert-butyldimethylsilyl (TBS) group. This compound is specifically engineered for use in complex multi-step syntheses, where its bromine and protected hydroxymethyl functionalities serve as key handles for further derivatization. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the construction of novel active molecules.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly those targeting kinase inhibition or other biological pathways where the furo[3,2-b]pyridine scaffold is relevant.
• Agrochemical Research: Used in the development of new active ingredients for crop protection, leveraging its heterocyclic structure for bioactivity.
• Material Science Precursor: Serves as a specialized monomer or precursor for creating organic electronic materials or ligands for catalytic systems.
• Chemical Biology Probe Synthesis: Utilized to create tagged or modified molecular probes for studying biological mechanisms and target engagement.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.
• Academic Research: Employed in university and institutional laboratories for methodological development and exploring new chemical spaces in heterocyclic chemistry.

Basic Information

Product Name	6-Bromo-2-((tert-Butyldimethylsilyloxy)Methyl)-Furo[3,2-B]Pyridine
CAS No.	1171920-23-2
Molecular Formula	C15H22BrNO2Si
Molecular Weight	356.34 g/mol
Synonyms	6-Bromo-2-(((tert-butyldimethylsilyl)oxy)methyl)furo[3,2-b]pyridine; 2-(((tert-Butyldimethylsilyl)oxy)methyl)-6-bromofuro[3,2-b]pyridine; 6-Bromo-2-((TBDMS-Oxy)Methyl)Furo[3,2-B]Pyridine; TBS-protected 6-Bromo-2-(hydroxymethyl)furo[3,2-b]pyridine; 6-Bromo-2-((tert-butyldimethylsilanyloxy)methyl)furo[3,2-b]pyridine; 1171920-23-2; Furo[3,2-b]pyridine, 6-bromo-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-
EINECS	Contact for details

Quality Control

Every batch of 6-Bromo-2-((tert-Butyldimethylsilyloxy)Methyl)-Furo[3,2-B]Pyridine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural identity for sensitive synthetic applications. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under an inert atmosphere when appropriate to ensure long-term stability. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.