Description

2-Chloro-3-(Dimethoxymethyl)-4-((Trimethylsilyl)-Ethynyl)Pyridine is a high-value, multi-functional pyridine derivative featuring both chloro and trimethylsilyl-protected ethynyl substituents. This compound serves as a critical advanced intermediate in modern synthetic organic chemistry, enabling the construction of complex molecular architectures. It is primarily sought after by pharmaceutical R&D and agrochemical sectors for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents and herbicides.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the development of specialty polymers and organic electronic materials.
• Cross-Coupling Reactions: The protected ethynyl group makes it a valuable substrate for Sonogashira and other palladium-catalyzed cross-coupling reactions.
• Ligand Synthesis: Utilized in the preparation of novel nitrogen-containing ligands for catalysis and coordination chemistry.
• Chemical Biology Probes: Acts as a scaffold for creating molecular probes and tags used in bio-conjugation and imaging studies.

Basic Information

Product Name	2-Chloro-3-(Dimethoxymethyl)-4-((Trimethylsilyl)-Ethynyl)Pyridine
CAS No.	1171920-13-0
Molecular Formula	C13H18ClNO2Si
Molecular Weight	283.82 g/mol
Synonyms	2-Chloro-3-(dimethoxymethyl)-4-[(trimethylsilyl)ethynyl]pyridine; 4-((Trimethylsilyl)ethynyl)-2-chloro-3-(dimethoxymethyl)pyridine; Pyridine, 2-chloro-3-(dimethoxymethyl)-4-[(trimethylsilyl)ethynyl]-; 2-Chloro-3-(dimethoxymethyl)-4-(trimethylsilylethynyl)pyridine; TMS-Ethynyl Pyridine Derivative; CAS 1171920-13-0
EINECS	Contact for details

Quality Control

Our production of 2-Chloro-3-(Dimethoxymethyl)-4-((Trimethylsilyl)-Ethynyl)Pyridine adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical characterization, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment. We support cGMP compliance for advanced intermediates intended for pharmaceutical use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.