Description

3-((Trimethylsilyl)Ethynyl)Pyridin-4-Ol is a high-purity organosilicon building block featuring a pyridine core functionalized with a trimethylsilyl-protected ethynyl group. This compound is valued for its role as a versatile synthetic intermediate in advanced organic and medicinal chemistry, enabling the construction of complex molecular architectures. It is primarily sought by research and development teams in the pharmaceutical, agrochemical, and material science industries for applications in drug discovery, ligand synthesis, and the development of functional polymers.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new crop protection agents and herbicides due to its functionalized heterocyclic structure.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the creation of advanced polymers, conductive materials, and metal-organic frameworks (MOFs).
• Ligand Synthesis: Employed in the preparation of sophisticated ligands for catalysis and coordination chemistry.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target engagement.
• Academic & Industrial R&D: A critical reagent for method development and exploratory synthesis in both university and corporate research laboratories.

Basic Information

Product Name	3-((Trimethylsilyl)Ethynyl)Pyridin-4-Ol
CAS No.	1171920-09-4
Molecular Formula	C10H13NOSi
Molecular Weight	191.31 g/mol
Synonyms	4-Hydroxy-3-((trimethylsilyl)ethynyl)pyridine; 3-(Trimethylsilylethynyl)pyridin-4-ol; 4-Pyridinol, 3-[(trimethylsilyl)ethynyl]-; 3-Ethynyl-4-hydroxypyridine, trimethylsilyl derivative; TMS-Ethynyl-4-hydroxypyridine; 1171920-09-4
EINECS	Contact for details

Quality Control

Our 3-((Trimethylsilyl)Ethynyl)Pyridin-4-Ol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant research and development standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.