Description

tert-Butyl (5-Pivalamidopyridin-3-Yl)-Methylcarbamate is a high-purity, advanced pharmaceutical intermediate characterized by its specific carbamate and pivalamido functional groups on a pyridine scaffold. This compound is of critical importance for its role in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research and development. It is primarily needed by pharmaceutical manufacturers and R&D organizations focused on developing novel therapeutic agents, including kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of targeted small-molecule drugs, especially in oncology and anti-inflammatory research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes to develop new chemical entities.
• API Synthesis: Serves as a crucial precursor in the production route of final Active Pharmaceutical Ingredients (APIs).
• Process Development & Scale-up: Employed in pilot plant and commercial-scale manufacturing process development for new pharmaceuticals.
• Biochemical Tool Compound: May be utilized in biochemical assays and as a probe for studying specific biological pathways.
• Custom Synthesis: A starting material for the custom synthesis of more complex, proprietary molecules for clinical trials.

Basic Information

Item	Detail
Product Name	tert-Butyl (5-Pivalamidopyridin-3-Yl)-Methylcarbamate
CAS No.	1171920-06-1
Molecular Formula	C16H25N3O3
Molecular Weight	307.39 g/mol
Synonyms	tert-Butyl N-[(5-pivalamidopyridin-3-yl)methyl]carbamate; BOC-Protected 5-Pivalamido-3-(aminomethyl)pyridine; 3-[[(tert-Butoxycarbonyl)amino]methyl]-5-(2,2-dimethylpropanamido)pyridine; 5-(Pivalamido)-3-((BOC-amino)methyl)pyridine; N-(3-((tert-Butoxycarbonylamino)methyl)pyridin-5-yl)pivalamide; (5-Pivalamidopyridin-3-yl)methylcarbamic acid tert-butyl ester; CAS 1171920-06-1
EINECS	Contact for details

Quality Control

Our tert-Butyl (5-Pivalamidopyridin-3-Yl)-Methylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring the material meets the stringent requirements for pharmaceutical R&D and manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.