Description

Methyl 3-(6-Bromo-5-Pivalamidopyridin-3-Yl)-Acrylate CAS NO 1171919-95-1 is a high-purity, functionalized pyridine derivative designed for advanced chemical synthesis. This compound serves as a critical building block in pharmaceutical research and development, enabling the construction of complex molecular architectures. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small molecule therapeutics.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its versatile acrylate and bromo functional groups.
• Agrochemical Synthesis: Serves as a building block for developing novel crop protection agents and pesticides.
• Chemical Biology Probes: Employed in the development of molecular probes and labeled compounds for target identification and validation studies.
• Cross-Coupling Reactions: The bromo substituent makes it a suitable substrate for palladium-catalyzed cross-coupling reactions, such as Suzuki or Buchwald-Hartwig amination.
• Fine Chemical Production: Used in the custom synthesis of specialty chemicals and complex organic molecules for various industrial applications.

Basic Information

Item	Details
Product Name	Methyl 3-(6-Bromo-5-Pivalamidopyridin-3-Yl)-Acrylate
CAS No.	1171919-95-1
Molecular Formula	C14H17BrN2O3
Molecular Weight	341.20 g/mol
Synonyms	Methyl (E)-3-(6-Bromo-5-(pivalamido)pyridin-3-yl)acrylate; 2-Methyl-N-[5-[(1E)-3-methoxy-3-oxoprop-1-en-1-yl]-6-bromopyridin-3-yl]-2-propanamide; 6-Bromo-5-(pivalamido)nicotinic Acid Methyl Ester Acrylate Derivative; Methyl 3-(6-Bromo-5-(2,2-dimethylpropanamido)pyridin-3-yl)prop-2-enoate; Piv-Protected Bromonicotinate Acrylate Ester; (E)-Methyl 3-(6-bromo-5-(pivalamido)pyridin-3-yl)acrylate; 1171919-95-1; Bromo-Piv-Nicotinate Acrylate
EINECS	Contact for details

Quality Control

Our Methyl 3-(6-Bromo-5-Pivalamidopyridin-3-Yl)-Acrylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which may affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.