Description

n-(2-Bromo-5-((tert-Butyldimethylsilyloxy)Methyl)-Pyridin-3-Yl)Pivalamide is a high-purity, advanced pharmaceutical intermediate designed for complex organic synthesis. This compound is valued for its role as a key building block in the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking reliable and high-quality synthetic precursors.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of novel drug candidates, especially in kinase inhibitor and other small-molecule therapeutic programs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its reactive bromo and protected hydroxymethyl functional groups.
• Process Chemistry Development: Serves as a standardized intermediate for scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Agrochemical Synthesis: Employed in the research and development of new crop protection agents and pesticides.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.
• Academic Research: Used in university and institutional labs for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	n-(2-Bromo-5-((tert-Butyldimethylsilyloxy)Methyl)-Pyridin-3-Yl)Pivalamide
CAS No.	1171919-94-0
Molecular Formula	C17H29BrN2O2Si
Molecular Weight	401.42 g/mol
Synonyms	2-Bromo-5-((tert-butyldimethylsilyloxy)methyl)-N-(2,2-dimethylpropanoyl)pyridin-3-amine; Pivalamide, N-[2-bromo-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-3-pyridinyl]-; 3-Amino-2-bromo-5-((tert-butyldimethylsilyloxy)methyl)pyridine Pivalamide; TBS-protected Bromopyridine Pivalamide Intermediate; 1171919-94-0; tert-Butyldimethyl((5-(pivalamido)-6-bromopyridin-3-yl)methoxy)silane
EINECS	Contact for details

Quality Control

Our n-(2-Bromo-5-((tert-Butyldimethylsilyloxy)Methyl)-Pyridin-3-Yl)Pivalamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliability for your critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation from moisture uptake. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.