Description

2-Chloro-4-Iodonicotinonitrile (CAS NO 1171919-75-7) is a versatile halogenated pyridine derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its unique structure, featuring both chloro and iodo substituents on the pyridine ring, makes it a valuable scaffold for constructing complex molecules through selective cross-coupling and substitution reactions. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

2-Chloro-4-Iodonicotinonitrile is a key building block in medicinal and process chemistry. Its primary applications include:

• Pharmaceutical Intermediate: Serves as a core scaffold for the synthesis of potential drug candidates, particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Material Science Precursor: Acts as a starting material for creating functionalized ligands, organic semiconductors, and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: The iodine substituent is highly reactive in palladium-catalyzed couplings (e.g., Suzuki, Sonogashira), while the chlorine allows for sequential functionalization.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new reaction methodologies and constructing heterocyclic libraries.

Basic Information

Product Name	2-Chloro-4-Iodonicotinonitrile
CAS No.	1171919-75-7
Molecular Formula	C6H2ClIN2
Molecular Weight	264.45 g/mol
Synonyms	2-Chloro-4-iodopyridine-3-carbonitrile; 3-Cyano-2-chloro-4-iodopyridine; 4-Iodo-2-chloronicotinonitrile; 2-Chloro-4-iodo-3-pyridinecarbonitrile; 2-Chloro-4-iodo-3-cyanopyridine; Nicotinonitrile, 2-chloro-4-iodo-; 1171919-75-7
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Iodonicotinonitrile is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural identity. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting purity, assay, and impurity profiles. Our quality systems are designed to support cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light). Keep the container tightly sealed in a dry environment to minimize moisture uptake and ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.