Description

Methyl 2-Amino-3-Chloro-5-(Trifluoromethyl)-Isonicotinate is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its core value lies in its unique trifluoromethylpyridine scaffold, which imparts desirable properties like metabolic stability and enhanced lipophilicity to target molecules. This compound is critically needed by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, including potential drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Serves as a critical building block for developing next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances bioactivity and environmental stability.
• Material Science Research: Used in the creation of advanced organic materials, such as liquid crystals, organic semiconductors, and specialty polymers with tailored electronic properties.
• Chemical Biology & Proteomics: Employed as a scaffold or labeling agent in the design of molecular probes and enzyme inhibitors for biochemical research and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and complex molecules under cGMP conditions.

Basic Information

Product Name	Methyl 2-Amino-3-Chloro-5-(Trifluoromethyl)-Isonicotinate
CAS No.	1171919-10-0
Molecular Formula	C8H6ClF3N2O2
Molecular Weight	254.59 g/mol
Synonyms	2-Amino-3-chloro-5-(trifluoromethyl)isonicotinic acid methyl ester; Methyl 2-amino-3-chloro-5-(trifluoromethyl)pyridine-4-carboxylate; 3-Chloro-2-amino-5-trifluoromethyl-isonicotinic acid methyl ester; 4-Pyridinecarboxylic acid, 2-amino-3-chloro-5-(trifluoromethyl)-, methyl ester; 2-Amino-3-chloro-5-trifluoromethyl-4-pyridinecarboxylic acid methyl ester; Methyl 2-amino-3-chloro-5-(trifluoromethyl)-4-pyridinecarboxylate
EINECS	Contact for details

Quality Control

Our production of Methyl 2-Amino-3-Chloro-5-(Trifluoromethyl)-Isonicotinate adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects with material suitable for research use and can supply under cGMP guidelines for advanced clinical phases upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.