Description

Ethyl 8-Iodo-2,6-Bis(Trifluoromethyl)Imidazo-[1,2-A]Pyridine-3-Carboxylate is a high-value, multi-functionalized heterocyclic building block designed for advanced synthetic chemistry. This compound is critical for researchers and process chemists developing novel active pharmaceutical ingredients (APIs) and agrochemicals, where the introduction of iodine and trifluoromethyl groups is strategically important. Its primary utility lies in facilitating cross-coupling reactions and serving as a versatile precursor in medicinal chemistry and material science applications.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in the development of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Research: Used in the discovery and development of new-generation pesticides and herbicides, leveraging the bioactivity-enhancing properties of the trifluoromethyl and halogenated imidazopyridine core.
• Material Science Precursor: Serves as a specialized monomer or functional additive in the synthesis of advanced organic electronic materials, such as OLEDs or conductive polymers.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira, Heck) to create complex molecular architectures.
• Medicinal Chemistry SAR Studies: Employed in structure-activity relationship (SAR) studies to explore and optimize the biological activity of lead compounds.
• Fluorine Chemistry: A valuable reagent for introducing fluorine-containing motifs into target molecules, a common strategy to improve metabolic stability and membrane permeability.

Basic Information

Item	Details
Product Name	Ethyl 8-Iodo-2,6-Bis(Trifluoromethyl)Imidazo-[1,2-A]Pyridine-3-Carboxylate
CAS No.	1171918-86-7
Molecular Formula	C13H7F6IN2O2
Molecular Weight	464.11 g/mol
Synonyms	8-Iodo-2,6-bis(trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester; Ethyl 8-iodo-2,6-bis(trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxylate; 1171918-86-7; Imidazo[1,2-a]pyridine-3-carboxylic acid, 8-iodo-2,6-bis(trifluoromethyl)-, ethyl ester; Ethyl 8-iodo-2,6-di(trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxylate
EINECS	Contact for details

Quality Control

Every batch of Ethyl 8-Iodo-2,6-Bis(Trifluoromethyl)Imidazo-[1,2-A]Pyridine-3-Carboxylate is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation, and impurity profile is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.