Description

Methyl 5-Chloro-6-Fluoronicotinate is a high-purity fluorinated pyridine derivative that serves as a critical building block in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, enabling precise molecular modifications. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex heterocyclic frameworks.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of fluorinated drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the chloro-fluoro substitution pattern enhances biological activity and environmental stability.
• Material Science Research: Serves as a monomer or functionalization agent for creating specialty polymers and liquid crystals with unique electronic properties.
• Chemical Biology Probes: Employed in the design of fluorinated probes and tags for studying biological mechanisms and enzyme interactions.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring regioselectively halogenated nicotinate scaffolds.

Basic Information

Product Name	Methyl 5-Chloro-6-Fluoronicotinate
CAS No.	1171918-85-6
Molecular Formula	C7H5ClFNO2
Molecular Weight	189.57 g/mol
Synonyms	Methyl 5-chloro-6-fluoropyridine-3-carboxylate; 5-Chloro-6-fluoro-3-pyridinecarboxylic acid methyl ester; 3-Pyridinecarboxylic acid, 5-chloro-6-fluoro-, methyl ester; Methyl 5-chloro-6-fluoronicotinate; 5-Chloro-6-fluoronicotinic acid methyl ester; 1171918-85-6
EINECS	Contact for details

Quality Control

Our Methyl 5-Chloro-6-Fluoronicotinate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to ICH guidelines for analytical method validation, ensuring data integrity and reliability for critical R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.