Description

3,5-Difluoro-2-Methoxypyridine is a high-purity fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of fluorine and methoxy substituents, which are essential for modulating the electronic properties, lipophilicity, and metabolic stability of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of modern pesticides and herbicides, where the difluoromethoxypyridine moiety contributes to enhanced biological activity and environmental profile.
• Material Science Precursor: Employed in the synthesis of specialized ligands for catalysis and as a building block for advanced organic electronic materials.
• Chemical Research & Development: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Fluorine Chemistry: Acts as a valuable substrate for further functionalization via cross-coupling and nucleophilic substitution reactions, leveraging its reactive halogen sites.

Basic Information

Product Name	3,5-Difluoro-2-Methoxypyridine
CAS No.	1171918-06-1
Molecular Formula	C6H5F2NO
Molecular Weight	145.11 g/mol
Synonyms	2-Methoxy-3,5-difluoropyridine; 3,5-Difluoro-2-methoxypyridine; 2-Methoxy-3,5-difluoropyridine; Pyridine, 3,5-difluoro-2-methoxy-; 1171918-06-1
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-2-Methoxypyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.