Description

n-Methyl-1-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yl)Methanamine is a high-value, functionalized pyridine boronic ester derivative, serving as a critical advanced pharmaceutical intermediate (API) and versatile Suzuki-Miyaura cross-coupling building block. Its molecular architecture, featuring both a protected amine and a boronate ester group, enables precise and efficient construction of complex molecules for drug discovery and materials science. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and other small molecule drug candidates.
• Suzuki-Miyaura Cross-Coupling Reactions: Enables the formation of carbon-carbon bonds between the pyridine ring and various aryl/heteroaryl halides, essential for constructing complex molecular scaffolds.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides requiring specific heterocyclic architectures.
• Ligand Synthesis: Precursor for creating novel bidentate or tridentate ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science: Building block for organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	n-Methyl-1-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yl)Methanamine
CAS No.	1171893-98-3
Molecular Formula	C13H21BN2O2
Molecular Weight	248.13 g/mol
Synonyms	3-((Methylamino)methyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-((methylamino)methyl)pyridine; 3-Pyridinemethanamine, N-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; (5-((Methylamino)methyl)pyridin-3-yl)boronic acid pinacol ester; CAS 1171893-98-3
EINECS	Contact for details

Quality Control

Our n-Methyl-1-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yl)Methanamine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Recommended storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.