Description

1-Methyl-4-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yl)Piperazine is a high-value boronic ester derivative and a key synthetic intermediate in modern organic chemistry. Its core value lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of pharmaceutical and advanced materials synthesis. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-purity building blocks for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of novel crop protection agents and herbicides through structure-activity relationship (SAR) studies.
• Material Science: Serves as a monomer or precursor in the creation of organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and labeled compounds for biochemical and diagnostic applications.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura cross-coupling to introduce the pyridinylpiperazine moiety into complex molecules.
• Library Synthesis: A valuable reagent for medicinal chemistry teams engaged in parallel and combinatorial synthesis to generate diverse compound libraries for screening.

Basic Information

Product Name	1-Methyl-4-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yl)Piperazine
CAS No.	1171892-37-7
Molecular Formula	C16H26BN3O2
Molecular Weight	303.21 g/mol
Synonyms	1-Methyl-4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinyl]piperazine; 3-(4-Methylpiperazin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 1-Methyl-4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)piperazine; 5-(4-Methylpiperazin-1-yl)pyridine-3-boronic acid pinacol ester; 1171892-37-7; 1-Methyl-4-[5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl]piperazine
EINECS	Contact for details

Quality Control

Our 1-Methyl-4-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yl)Piperazine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with REACH and other global regulatory frameworks as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.