Description

2-(Dimethoxymethyl)-4-(Trifluoromethyl)-1H-Imidazole is a specialized heterocyclic building block featuring a reactive imidazole core functionalized with a dimethoxymethyl protecting group and a trifluoromethyl substituent. This compound is of significant value in advanced organic synthesis, particularly for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where the trifluoromethyl group is prized for its ability to modulate lipophilicity, metabolic stability, and bioavailability. It is primarily sought by research and development chemists, process development teams, and manufacturers in the pharmaceutical, agrochemical, and advanced material sectors.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex molecules in medicinal chemistry, especially for candidates targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Ligand and Catalyst Development: Serves as a precursor for creating novel N-heterocyclic carbene (NHC) ligands or metal-organic frameworks (MOFs) used in catalysis.
• Material Science Research: Employed in the synthesis of specialty polymers, liquid crystals, or electronic materials where the imidazole ring contributes to specific electronic or thermal properties.
• Custom Synthesis and Contract Manufacturing: A critical building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2-(Dimethoxymethyl)-4-(Trifluoromethyl)-1H-Imidazole
CAS No.	1171125-25-9
Molecular Formula	C7H9F3N2O2
Molecular Weight	210.16 g/mol
Synonyms	4-(Trifluoromethyl)-1H-imidazole-2-carboxaldehyde dimethyl acetal; 1H-Imidazole-2-carboxaldehyde, 4-(trifluoromethyl)-, dimethyl acetal; 2-(Dimethoxymethyl)-4-(trifluoromethyl)imidazole; 4-(Trifluoromethyl)-2-(dimethoxymethyl)-1H-imidazole
EINECS	Contact for details

Quality Control

Our 2-(Dimethoxymethyl)-4-(Trifluoromethyl)-1H-Imidazole is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.