Description

6-Amino-2-Azaspiro[3.3]heptane-6-carboxylic Acid HCl is a high-value, pharmaceutically relevant building block featuring a constrained spirocyclic scaffold. This compound is essential for medicinal chemistry research and development, offering unique three-dimensional geometry to modulate the biological activity and physicochemical properties of drug candidates. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of small molecule drug candidates targeting central nervous system (CNS) disorders, metabolic diseases, and infectious diseases.
• Medicinal Chemistry Research: Used to introduce a rigid, spirocyclic amine-acid motif into compound libraries for structure-activity relationship (SAR) studies and lead optimization.
• Peptidomimetic Design: Serves as a constrained amino acid analog in the design of novel peptidomimetics and macrocyclic compounds to enhance metabolic stability and binding affinity.
• Process Chemistry & Scale-up: Employed in the development and kilogram-scale production of active pharmaceutical ingredients (APIs) for preclinical and clinical trials.
• Chemical Biology Probes: Utilized in the synthesis of chemical probes for investigating enzyme function and protein-protein interactions.

Basic Information

Product Name	6-Amino-2-Azaspiro[3.3]heptane-6-carboxylic Acid HCl
CAS No.	1170461-72-9
Molecular Formula	C7H13ClN2O2
Molecular Weight	192.64 g/mol
Synonyms	6-Amino-2-azaspiro[3.3]heptane-6-carboxylic acid hydrochloride; 2-Azaspiro[3.3]heptane-6-carboxylic acid, 6-amino-, hydrochloride; 6-Amino-2-azaspiro[3.3]heptane-6-carboxylic acid HCl; 6-Aza-spiro[3.3]heptane-6-carboxylic acid, 6-amino-, hydrochloride; (6-Amino-2-azaspiro[3.3]heptan-6-yl)carboxylic acid hydrochloride; 1170461-72-9; 6-Amino-2-azaspiro[3.3]heptane-6-carboxylic acid hydrochloride salt
EINECS	Contact for details

Quality Control

Our 6-Amino-2-Azaspiro[3.3]heptane-6-carboxylic Acid HCl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.