Description

1H-Indazole-1-Carboxylic Acid, 6-Bromo-4-Methoxy-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its specific indazole core and bromo-methoxy substitution pattern. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for oncology and central nervous system (CNS) therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical entities.
• Organic Synthesis Building Block: Serves as a versatile scaffold for constructing complex heterocyclic compounds in academic and industrial R&D laboratories.
• Process Chemistry Development: Employed in route scouting and scale-up studies for the commercial manufacturing of potential APIs.
• Bioconjugation & Probe Development: Can be utilized in the creation of chemical probes for biochemical and pharmacological assays.

Basic Information

Product Name	1H-Indazole-1-Carboxylic Acid, 6-Bromo-4-Methoxy-, 1,1-Dimethylethyl Ester
CAS No.	1169789-29-0
Molecular Formula	C14H17BrN2O3
Molecular Weight	341.20 g/mol
Synonyms	tert-Butyl 6-bromo-4-methoxy-1H-indazole-1-carboxylate; 6-Bromo-4-methoxy-1H-indazole-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-6-bromo-4-methoxy-1H-indazole; Boc-6-Bromo-4-methoxyindazole; 6-Bromo-4-methoxy-1H-indazole-1-carboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our production of 1H-Indazole-1-Carboxylic Acid, 6-Bromo-4-Methoxy-, 1,1-Dimethylethyl Ester adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical quality attributes are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.