Description

2-Chloro-5-(Trifluoromethyl)Pyridine-4-Boronic Acid is a high-value, multi-functional boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical Suzuki-Miyaura cross-coupling building block, enabling the efficient construction of complex biaryl and heterobiaryl structures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of advanced intermediates and active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Material Science Research: Employed in the development of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its electron-deficient pyridine core.
• Ligand and Catalyst Development: Serves as a building block for creating novel bidentate ligands and organometallic catalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2-Chloro-5-(Trifluoromethyl)Pyridine-4-Boronic Acid
CAS No.	1167437-28-6
Molecular Formula	C6H4BClF3NO2
Molecular Weight	225.36 g/mol
Synonyms	4-Borono-2-chloro-5-(trifluoromethyl)pyridine; [2-Chloro-5-(trifluoromethyl)pyridin-4-yl]boronic acid; 2-Chloro-5-trifluoromethyl-4-pyridineboronic acid; 2-Chloro-5-(trifluoromethyl)-4-pyridinylboronic Acid; 2-Chloro-5-(trifluoromethyl)pyridine-4-boronic Acid Pinacol Ester (common precursor); 2-Chloro-5-(trifluoromethyl)-4-pyridineboronic acid; 4-Pyridineboronic acid, 2-chloro-5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-(Trifluoromethyl)Pyridine-4-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.