Description

tert-Butyl 6-benzyl-2,6-diazaspiro[3.3]heptane-2-carboxylate is a high-value, protected spirocyclic amine building block essential for modern drug discovery. This compound matters because it provides a rigid, three-dimensional scaffold that is crucial for modulating the pharmacokinetic and pharmacodynamic properties of new therapeutic candidates. Pharmaceutical researchers and medicinal chemists need it for the synthesis of novel small molecule drugs, particularly in the development of central nervous system (CNS) and oncology targets.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex active pharmaceutical ingredients (APIs) targeting G protein-coupled receptors (GPCRs).
• Medicinal Chemistry Scaffold: Used to introduce a conformationally restricted, spirocyclic diamine moiety into lead compounds to improve selectivity and metabolic stability.
• PROTAC (Proteolysis Targeting Chimera) Development: Serves as a versatile linker component connecting E3 ligase ligands to target protein binders.
• Chemical Biology Probes: Employed in the construction of molecular tools for studying enzyme function and protein-protein interactions.
• Peptidomimetic Research: The 2,6-diazaspiro[3.3]heptane core is a privileged structure for mimicking peptide turn motifs in drug design.
• Library Synthesis for High-Throughput Screening: Used to generate diverse compound libraries for biological screening against novel disease targets.

Basic Information

Product Name	tert-Butyl 6-benzyl-2,6-diazaspiro[3.3]heptane-2-carboxylate
CAS No.	1167424-93-2
Molecular Formula	C17H24N2O2
Molecular Weight	288.39 g/mol
Synonyms	2,6-Diazaspiro[3.3]heptane-2-carboxylic acid, 6-(phenylmethyl)-, 1,1-dimethylethyl ester; 6-Benzyl-2,6-diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester; Boc-6-Bn-2,6-diazaspiro[3.3]heptane; tert-Butyl 6-benzyl-2,6-diazaspiro[3.3]heptane-2-carboxylate; 2-(tert-Butoxycarbonyl)-6-benzyl-2,6-diazaspiro[3.3]heptane; 6-Benzyl-2-N-Boc-2,6-diazaspiro[3.3]heptane
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-benzyl-2,6-diazaspiro[3.3]heptane-2-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our production adheres to cGMP guidelines where applicable, ensuring material traceability and reliability for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.