Description

4-(1-[3-Chloro-5-(Trifluoromethyl)-2-Pyridinyl]-1H-Indol-3-Yl)-3-Buten-2-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique heterocyclic structure. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers targeting innovative therapeutic areas. The product is supplied with full analytical documentation to ensure traceability and support regulatory submissions.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its complex pyridine-indole scaffold.
• Agrochemical Development: Potential application in the research and synthesis of new-generation pesticides and herbicides, leveraging its halogenated structure.
• Chemical Biology Probes: Employed in the development of molecular probes for studying biological pathways and target validation.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs engaged in custom synthesis projects for client-specific molecules.

Basic Information

Product Name	4-(1-[3-Chloro-5-(Trifluoromethyl)-2-Pyridinyl]-1H-Indol-3-Yl)-3-Buten-2-One
CAS No.	1164455-16-6
Molecular Formula	C18H12ClF3N2O
Molecular Weight	364.75 g/mol
Synonyms	4-[1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]indol-3-yl]but-3-en-2-one; (E)-4-(1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1H-indol-3-yl)but-3-en-2-one; 4-(1-(3-Chloro-5-(trifluoromethyl)-2-pyridinyl)-1H-indol-3-yl)-3-buten-2-one; CAS 1164455-16-6; 3-Buten-2-one, 4-[1-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-1H-indol-3-yl]-; 4-(1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1H-indol-3-yl)but-3-en-2-one
EINECS	Contact for details

Quality Control

Our 4-(1-[3-Chloro-5-(Trifluoromethyl)-2-Pyridinyl]-1H-Indol-3-Yl)-3-Buten-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR/LC-MS for structural confirmation, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee batch-to-batch consistency and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain product integrity. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Single Maximum Unknown Impurity	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.